Applied Pharmacokinetics and Pharmacodynamics and Population Analysis with NONMEM
Link to Spanish Version
OVERVIEW
This is a pharmacology course, taught by international teachers, organized by the Division of Anesthesiology, Faculty of Medicine, Catholic University of Chile. It is an introductory course to pharmacokinetic and pharmacodynamic (PKPD) principles and population analysis of PKPD data in the medical and pharmaceutical sciences using the NONMEM program.
FOR WHOM INTENDED
The Course is designed for those who have knowledge of basic concepts in pharmacokinetics, pharmacodynamics and data analysis and who now wish to extend their understanding, acquiring skills in the population analysis of PKPD data with NONMEM.
REQUIREMENTS
Intermediate English, user-level knowledge of Windows programs and Internet browsing. Participants should come with a scientific calculator and a Windows based laptop (mandatory for NONMEM hands on workshop).
SPECIFIC OBJECTIVES AND CONTENTS
Objectives:
– Review the basic principles of pharmacokinetics and pharmacodynamics.
– Understand the importance of linking the emergence and spread of drug effects with time.
– Understand the population analysis of PKPD data with NONMEM.
Contents:
– Absorption, distribution and elimination processes.
– Drug administration.
– Basic pharmacodynamics (receptors and interactions).
– Pharmacodynamics and time course of drug effect.
– Disease Progression.
– NONMEM population analysis.
– Building and evaluation of population PKPD models.
A course manual, comprising lecture outlines, derivations, problem sets with answers, and additional reading material will be provided in an electronic format.
TUTORS
Leon Aarons, PhD ([email protected])
Leon Aarons is a Professor in the School of Pharmacy and Pharmaceutical Sciences, University of Manchester, UK. His research interest are in population and physiologically based pharmacokinetics.
Nick Holford, MBChB, MSc, FRACP ([email protected])
Nick Holford is Professor of Clinical Pharmacology at the University of Auckland, Auckland, New Zealand. His main interests are PKPD modelling. He has particular interests in describing disease progression, influence of drug treatments on disease and dosing of children.
Steve Duffull, MPharm, PhD, FNZCP. ([email protected])
Stephen Duffull is Professor of Clinical Pharmacy at the University of Otago, Dunedin, New Zealand. He runs the Otago Pharmacometrics Groupwithin the School of Pharmacy. Research interests include optimal design, MCMC methods particularly in clinical toxicology and haemostasis. He has been involved in the area of PKPD and nonlinear mixed effects modelling for 20 years.
METHODOLOGY
Lectures of 45-60 minutes each, small-group workshops and tutorial discussion sessions.
GENERAL INFORMATION
Date: August 30 to September 4, 2015
Hours: 8:30 to 17:00 hrs.
Duration: 30 hrs.
Location: UC Extension Center
Vacancies: 40 students
Cost:
| Hasta el 30/06/2015 | Desde el 01/07/2015 |
| $ 900.000 CLP (US 1.400) | $ 1.200.000 CLP (US 1.900) |
INFORMATION AND CONTACT
Verónica García
Coordinadora de Extensión
Escuela de Medicina
Pontificia Universidad Católica de Chile
Lira 44, piso 1, Santiago – Chile
(56-02) 2354-6420
Link to COURSE PROGRAM