The Sheiner-Rowland Advanced Course in PKPD Leiden 2019

Monday 15th to Wednesday 17th April 2019

An advanced course presenting aspects and applications of pharmacokinetics, pharmacodynamics and kinetic/dynamic data analysis in the medical and pharmaceutical sciences.

For whom intended:
The Course is designed for those who have a good working knowledge of basic concepts in pharmacokinetics, pharmacodynamics and data analysis and who now wish to extend their knowledge further. Emphasis will be placed on relating pharmacokinetics to underlying physiological processes and to pharmacodynamics, and on the analysis and modelling of pharmacokinetic and pharmacodynamic data.

Course content: 
The mornings will be devoted to lectures; the afternoons to small-group workshops led by experienced tutors, in which participants will solve practical problems and develop facility with the techniques and approaches discussed in the lectures. The participants are encouraged to raise questions from their experience for discussion: time is specifically reserved for informal consultations.

Course manual: 
A course manual, comprising lecture outlines, derivations, problem sets with answers, and additional reading material will be provided in an electronic format.

This is not a computer modelling training course. There are no computer exercises. However, participants should come with a scientific hand calculator or notebook computer.

Ability to understand and converse in English is essential.


Monday 15th April

08:45-09:00                Introduction (Leon Aarons)

09:00-10:15                Lecture 1 – Empirical Pharmacokinetics (Leon Aarons)

10:15-10:45                Coffee

10:45-12:00                Lecture 2 – Principles of Pharmacodynamics (Nick Holford)

12:30-14:00                Lunch

14:00-17:00                Workshop I – Empirical PK and PD

17:00-18:00                Consultation (optional)

Tuesday 16th April

09:00-10:15                Lecture 3 – Physiologically Based Pharmacokinetics (Leon Aarons)

10:15-10:45                Coffee

10:45-12:00                Lecture 4 – Principles of Pharmacokinetics and Pharmacodynamics (Nick Holford)

12:30-14:00                Lunch

14:00-17:00                Workshop II – PBPK and PKPD

17:00-18:00                Consultation (optional)

Wednesday 17th April

09:00-10:15                Lecture 5 – Principles of Disease Progression (Nick Holford)

10:15-10:45                Coffee

10:45-12:15                Workshop III – Disease Progression